Division of Stem Cell and Developmental Biology, Ontario Cancer Institute, Canada.
Trends Mol Med. 2010 Mar;16(3):145-51. doi: 10.1016/j.molmed.2010.01.001. Epub 2010 Feb 10.
One issue in human cancer research that remains largely unresolved is the identity of the normal cell type in which tumorigenesis begins. Knowledge of the starting cell populations targeted by transforming events is crucial for characterizing early neoplastic changes and understanding how normal cellular processes become disrupted during cancer development. Recent focus on cancer stem cells (CSCs) has been accompanied by the frequent assumption that these cells derive from normal stem cells. However, evidence from mouse tumor models has demonstrated that cancer can also arise from committed progenitors. This review highlights recent insights gained from studies of the normal cell populations targeted for malignant transformation - in other words, the cellular origins of cancer.
在人类癌症研究中，一个仍然基本未解决的问题是肿瘤发生开始时的正常细胞类型。了解转化事件靶向的起始细胞群体对于描述早期肿瘤变化以及理解正常细胞过程在癌症发展过程中如何受到干扰至关重要。最近对癌症干细胞（CSCs）的关注伴随着一个常见的假设，即这些细胞源自正常干细胞。然而，来自小鼠肿瘤模型的证据表明，癌症也可以源自定向祖细胞。这篇综述强调了最近从针对恶性转化的正常细胞群体研究中获得的见解，换句话说，即癌症的细胞起源。
