Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176 Stockholm, Sweden.
Anticancer Res. 2010 Jan;30(1):261-3.
A case of massive fundic gland polyposis (MFGPsis) in a female patient receiving protracted proton-pump inhibitor (PPI) medication is described. At gross examination the majority of the polyps were overlapping, confluent, some of them having a "cauliflower-like" configuration. The fundic gland polyps (FGP) arose in the gastric acid secretory mucosa. The confluence of these polyps impeded their enumeration. The gross and histological characteristics of this case seemed to be at variance with syndromic or sporadic cases having multiple FGP, inasmuch as in this case, the FGP had a propensity to agglutinate, to overlap and to develop confluent macrocysts. Another difference was that this disease, refractory to antacid treatment, required surgical intervention. This case substantiates the notion that protracted PPI medication may encourage the development of MFGPsis in susceptible individuals.
本文描述了一位女性患者在接受长期质子泵抑制剂（PPI）治疗后出现巨大胃底腺息肉（MFGPsis）的病例。大体检查发现，大多数息肉重叠、融合，其中一些呈“菜花状”。胃底腺息肉（FGP）起源于胃酸分泌黏膜。这些息肉的融合阻碍了它们的计数。本例的大体和组织学特征似乎与多发性 FGP 的综合征或散发性病例不同，因为在本例中，FGP 有聚集、重叠和形成融合大囊的倾向。另一个不同之处在于，这种对抗酸治疗有抵抗力的疾病需要手术干预。该病例证实了长期使用 PPI 可能会促使易感个体发生 MFGPsis 的观点。
