Braeuninger Stefan, Kleinschnitz Christoph, Stoll Guido
Department of Neurology, Julius-Maximilians-Universitaet Wuerzburg, Josef-Schneider-Strasse 11, D-97080 Wuerzburg, Germany.
Exp Transl Stroke Med. 2010 Jan 5;2:1. doi: 10.1186/2040-7378-2-1.
Interleukin-18 (IL-18) is a proinflammatory cytokine of the interleukin-1 family which is upregulated after cerebral ischemia. The functional role of IL-18 in cerebral ischemia is unknown. In the present study, we compared infarct size in IL-18 knock-out and wild-type mice 24 hours and 48 hours after 1-hour transient middle cerebral artery occlusion (tMCAO). Moreover, the functional outcome was evaluated in a modified Bederson score, foot fault test and grip test. There were no significant differences in infarct size or functional outcome tests between wild-type and IL-18 knock-out mice. These data indicate that the early inflammatory response to cerebral ischemia does not involve IL-18, in contrast to other interleukin-1 family members such as interleukin-1.
白细胞介素-18（IL-18）是白细胞介素-1家族的一种促炎细胞因子，在脑缺血后上调。IL-18在脑缺血中的功能作用尚不清楚。在本研究中，我们比较了IL-18基因敲除小鼠和野生型小鼠在1小时短暂性大脑中动脉闭塞（tMCAO）后24小时和48小时的梗死面积。此外，通过改良的贝德森评分、足误试验和握力试验评估功能结局。野生型小鼠和IL-18基因敲除小鼠在梗死面积或功能结局测试方面没有显著差异。这些数据表明，与白细胞介素-1等其他白细胞介素-1家族成员不同，脑缺血的早期炎症反应不涉及IL-18。
