碘桥联双核铂（II）配合物的合成、表征及细胞毒性。
Synthesis, characterization and cytotoxicity of iodo-bridged binuclear platinum(II) complexes.
机构信息
College of Chemistry & Environmental Science, Chemical Biology Laboratory, Hebei University, and B-Ultrasound Room, Affiliated Hospital of Hebei University, Baoding 071002, China.
出版信息
Eur J Med Chem. 2010 Jun;45(6):2634-7. doi: 10.1016/j.ejmech.2010.01.055. Epub 2010 Jan 29.
Seven new iodo-bridged binuclear platinum(II) complexes [Pt(L)I2]2 (1-7) (L=n-butylamine, isopropylamine, m-toluidine, p-toluidine, diethylamine, N-methylaniline and aniline) have been synthesized and characterized by elemental analysis, conductivity, thermal analysis, IR, 1H NMR and mass spectra techniques. The cytotoxicity was tested by MTT assay. The results indicate that they have selectivity against tested carcinoma cell lines. For example, the complexes (3 and 7) have better cytotoxicity than cisplatin against Bel-7402 cell line, the complexes (2-5 and 7) have better cytotoxicity than cisplatin against Hela cell line. The results suggest that the species of amine has important effect on cytotoxicity, when L=m-toluidine, p-toluidine and aniline, the complexes have better cytotoxicity against tested carcinoma cell lines.
七种新型碘桥联双核铂(II)配合物[Pt(L)I2]2（1-7）（L=正丁胺、异丙胺、间甲苯胺、对甲苯胺、二乙胺、N-甲基苯胺和苯胺）已通过元素分析、电导率、热分析、IR、1H NMR 和质谱技术进行了合成和表征。通过 MTT 测定法测试了它们的细胞毒性。结果表明，它们对测试的癌细胞系具有选择性。例如，与顺铂相比，配合物（3 和 7）对 Bel-7402 细胞系具有更好的细胞毒性，与顺铂相比，配合物（2-5 和 7）对 Hela 细胞系具有更好的细胞毒性。结果表明，胺的种类对细胞毒性有重要影响，当 L=间甲苯胺、对甲苯胺和苯胺时，配合物对测试的癌细胞系具有更好的细胞毒性。
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