University Health Network and the University of Toronto, Toronto, Ontario, Canada.
J Clin Pathol. 2010 Feb;63(2):129-33. doi: 10.1136/jcp.2009.071423.
To review the clinicopathological, cytomorphological and immunophenotyping data from new cases and published series of thyroid lymphoma diagnosed by fine-needle aspiration (FNA), in order to identify useful diagnostic features.
Cases from 1988 to 2009 with an FNA diagnosis of thyroid lymphoma were selected from hospital records. An electronic MEDLINE and EMBASE search retrieved published series from 1980 to 2009. Available clinical, cytomorphological and immunophenotyping data from all cases were collected. In our cases, cytology slides and available surgical specimens were also reviewed.
There were nine cases from eight of our patients, and 70 reviewed cases from eight series with at least four patients each. The most common presentation was a rapidly enlarging thyroid mass. Average patient age was 61 years in reviewed cases and 72 years in our cases. Large-cell lymphoma was the predominant subtype, revealing relatively monotonous populations of large, abnormal lymphoid cells. One of our cases, later diagnosed as marginal zone lymphoma, showed small lymphocytes with plasmacytoid features. Immunoprofiling information was available in five of our cases (three by immunocytochemistry and two by laser scanning cytometry) and in 34 reviewed cases (22 by immunocytochemistry, six by flow cytometry, and six by flow cytometry or immunocytochemistry).
Cytological diagnosis of thyroid lymphoma requires careful analysis of morphological, clinical and immunophenotypic information. The presented data suggest certain helpful features: a fast-growing nodule in an elderly patient, a monotonous population of large abnormal cells in a background of lymphoglandular bodies, a predominant population of plasmacytoid lymphocytes, and immunophenotyping demonstrating light chain restriction.
回顾通过细针抽吸（FNA）诊断的甲状腺淋巴瘤的临床病理、细胞形态学和免疫表型数据，以确定有用的诊断特征。
从医院记录中选择 1988 年至 2009 年期间通过 FNA 诊断为甲状腺淋巴瘤的病例。通过电子 MEDLINE 和 EMBASE 检索，检索了 1980 年至 2009 年发表的系列文章。收集了所有病例的可用临床、细胞形态学和免疫表型数据。在我们的病例中，还回顾了细胞学载玻片和可用的手术标本。
我们的病例中有 8 名患者的 9 例，从 8 个系列中回顾了 70 例至少有 4 例患者的病例。最常见的表现是甲状腺肿块迅速增大。回顾性病例中患者的平均年龄为 61 岁，我们的病例中为 72 岁。大细胞淋巴瘤是最主要的亚型，揭示了相对单调的大异常淋巴细胞群体。我们的 1 例后来诊断为边缘区淋巴瘤的病例显示出具有浆细胞样特征的小淋巴细胞。我们的 5 例病例（3 例通过免疫细胞化学，2 例通过激光扫描细胞术）和 34 例回顾性病例（22 例通过免疫细胞化学，6 例通过流式细胞术，6 例通过流式细胞术或免疫细胞化学）中有免疫蛋白谱信息。
甲状腺淋巴瘤的细胞学诊断需要仔细分析形态学、临床和免疫表型信息。提出的数据表明了一些有用的特征：老年患者中快速生长的结节、淋巴腺滤泡背景下的大异常细胞单调群体、以浆细胞样淋巴细胞为主的群体以及免疫表型显示轻链受限。
