Department of Immunology, University of Texas and MD Anderson Cancer Center, Houston, Texas, USA.
Nat Immunol. 2010 Mar;11(3):250-6. doi: 10.1038/ni.1846. Epub 2010 Feb 14.
The physiological regulation of the expression of interleukin (IL)-9, a cytokine traditionally regarded as being T(H)2 associated, remains unclear. Here, we show that IL-9-expressing T cells generated in vitro in the presence of transforming growth factor-beta and IL-4 express high levels of mRNA for IL-17 receptor B (IL-17RB), the receptor for IL-25. Treatment of these cells with IL-25 enhances IL-9 expression in vitro. Moreover, transgenic and retroviral overexpression of IL-17RB in T cells results in IL-25-induced IL-9 production that is IL-4 independent. In vivo, the IL-25-IL-17RB pathway regulates IL-9 expression in allergic airway inflammation. Thus, IL-25 is a newly identified regulator of IL-9 expression.
白细胞介素 (IL)-9 的表达的生理调节仍然不清楚，白细胞介素-9 是一种传统上被认为与辅助性 T 细胞 2（T(H)2）相关的细胞因子。在这里，我们表明在转化生长因子-β和 IL-4 的存在下体外生成的表达白细胞介素-9 的 T 细胞表达高水平的白细胞介素-25 受体 (IL-17RB) 的 mRNA，IL-25 的受体。用 IL-25 处理这些细胞可增强体外的白细胞介素-9 表达。此外，T 细胞中转基因和逆转录病毒过表达 IL-17RB 导致 IL-25 诱导的白细胞介素-9 产生不依赖于白细胞介素-4。在体内，IL-25-IL-17RB 途径调节过敏性气道炎症中的白细胞介素-9 表达。因此，IL-25 是白细胞介素-9 表达的一种新发现的调节剂。
