Department of Neurology, Universidade Federal de São Paulo/UNIFESP, São Paulo, Brazil.
Prog Neuropsychopharmacol Biol Psychiatry. 2010 Apr 16;34(3):516-21. doi: 10.1016/j.pnpbp.2010.02.009. Epub 2010 Feb 13.
Evidence suggests increased prevalence of cluster B personality disorders (PD) among patients with juvenile myoclonic epilepsy (JME), which has been associated with worse seizure control and more psychosocial dysfunctions. A preliminary voxel-based morphometry study demonstrated corpus callosum (CC) volume reduction in patients with JME and cluster B PD, particularly in the posterior midbody and isthmus. In this study we aimed to follow up these results with region of interest analysis. Sixteen JME patients with cluster B PD, 38 JME patients without any psychiatric disorder, and 30 demographically matched healthy controls submitted to a psychiatric evaluation and a magnetic resonance imaging scan. The total and regional callosal areas were obtained from the midsagittal slice using a semi-automated program. Psychiatric evaluation was performed through SCID-I and -II. Significant reductions in the posterior region of the CC were observed in the JME with PD group relative to the other groups. These data support previous findings of callosal reductions in cluster B PD, as well as a possible involvement of CC in patients with JME and such personality characteristics.
证据表明，青少年肌阵挛性癫痫（JME）患者中 B 型人格障碍（PD）的患病率增加，这与癫痫控制更差和更多的社会心理功能障碍有关。一项初步的基于体素的形态计量学研究表明，JME 合并 B 型 PD 患者的胼胝体（CC）体积减少，特别是在后体中部和峡部。在这项研究中，我们旨在通过感兴趣区域分析来跟进这些结果。16 名 JME 合并 B 型 PD 患者、38 名 JME 无任何精神障碍患者和 30 名人口统计学匹配的健康对照者接受了精神科评估和磁共振成像扫描。使用半自动程序从正中矢状面获得总 CC 和区域性 CC 面积。通过 SCID-I 和 -II 进行精神病学评估。与其他组相比，PD 组的 CC 后区明显缩小。这些数据支持以前关于 B 型 PD 患者 CC 减少的发现，以及 CC 可能参与 JME 患者和此类人格特征。
