Synthesis of the Naturally Occurring (-)-1,3,5-Tri-O-Caffeoylquinic Acid.
作者信息
Brummond Kay M, Deforrest Jolie E
机构信息
Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA Fax +1(412)6248611;
出版信息
Synlett. 2009 Feb 11;9:1517-1519. doi: 10.1055/S-0029-1217183.
Abstract
Ribonuclease H (RNase H) is an essential component to the replication of human immunodeficiency virus (HIV), and only a few inhibitors of this enzyme are known. Millenia Hope Pharmaceuticals Inc. found that (-)-1,3,5-tri-O-caffeoylquinic acid is a potent RNase H inhibitor and antiviral agent. A facile route leading to this inhibitor from commercially available (-)-quinic acid is reported within.
摘要
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