兔眼内的水流动

Water movement in the rabbit eye.

作者信息

Cheng H M, Kwong K K, Dixon S, Tanaka G, Xiong J, Moore G, Chesler D A

机构信息

Howe Laboratory of Ophthalmology, Harvard Medical School, Boston, MA 02114.

出版信息

Exp Eye Res. 1991 Mar;52(3):337-9. doi: 10.1016/0014-4835(91)90098-y.

DOI:10.1016/0014-4835(91)90098-y

PMID:2015863

Abstract

The intraocular distribution of topically applied D2O was quantified using deuterium nuclear magnetic resonance (NMR) spectroscopy. D2O appeared in all tissues with the highest concentration in the aqueous humor (1.2 M); however, it rapidly dissipated from the eye. Surface coil NMR spectroscopy on D2O-treated eyes in vivo showed that the flow pattern was best described by a single exponential decay plus a constant. This suggests that the D2O flow consisted of a flow component representing vascular circulation (with a flow rate constant of 0.101 min-1), and a reservoir-like component. Topical D2O in conjunction with the surface-coil NMR technique can be used to examine the movement of water in the anterior segment of the living eye.

摘要

使用氘核磁共振（NMR）光谱法定量测定局部应用重水（D2O）的眼内分布。D2O出现在所有组织中，房水中浓度最高（1.2M）；然而，它会迅速从眼中消散。对体内经D2O处理的眼睛进行表面线圈NMR光谱分析表明，流动模式最好用单指数衰减加常数来描述。这表明D2O流动由代表血管循环的流动成分（流速常数为0.101 min-1）和类似储库的成分组成。局部应用D2O结合表面线圈NMR技术可用于检查活体眼前节水的运动。