大鼠胃底中组氨酸脱羧酶基因的表达受胃泌素调节。

Histidine decarboxylase gene expression in rat fundus is regulated by gastrin.

作者信息

Dimaline R, Sandvik A K

机构信息

Department of Physiology, University of Liverpool, UK.

出版信息

FEBS Lett. 1991 Apr 9;281(1-2):20-2. doi: 10.1016/0014-5793(91)80348-7.

DOI:10.1016/0014-5793(91)80348-7

PMID:2015894

Abstract

The conversion of histidine to histamine by histidine decarboxylase (HDC) is of central importance in the control of vertebrate acid secretion. We have used PCR-generated probes to study the regulation of HDC gene expression in rat fundic mucosa. When circulating gastrin levels were lowered by fasting or elevated by treatment with omeprazole, there were parallel changes in HDC mRNA abundance. However, when animals with elevated gastrin levels were concurrently treated with the gastrin/CCK-B receptor antagonist PD 134308, HDC mRNA levels were not increased. These data are consistent with the hypothesis that HDC gene expression is regulated by gastrin, over the physiological range of circulating hormone concentrations.

摘要

组氨酸脱羧酶（HDC）将组氨酸转化为组胺在脊椎动物胃酸分泌的控制中至关重要。我们使用聚合酶链反应（PCR）生成的探针来研究大鼠胃底黏膜中HDC基因表达的调控。当通过禁食降低循环胃泌素水平或通过奥美拉唑治疗升高循环胃泌素水平时，HDC mRNA丰度会发生相应变化。然而，当胃泌素水平升高的动物同时接受胃泌素/缩胆囊素B（CCK-B）受体拮抗剂PD 134308治疗时，HDC mRNA水平并未升高。这些数据与以下假设一致，即在循环激素浓度的生理范围内，HDC基因表达受胃泌素调控。