133例特发性男性不育患者的染色体核型及Y染色体微缺失分析
[Chromosome karyotype and Y chromosome microdeletion analysis in 133 idiopathic male infertile patients].
作者信息
Ji Yan, Xu Hong-jia, Huang Jian-chu
机构信息
Department of Obstetrics and Gynecology, Huizhou Municipal Central Hospital, Huizhou 516000, China. jiyanqurong163@com
出版信息
Nan Fang Yi Ke Da Xue Xue Bao. 2010 Feb;30(2):388-90.
OBJECTIVE
To explore the relationship between chromosomal abnormalities and Y chromosome microdeletions in idiopathic male infertile patients.
METHODS
Karyotypic analysis and PCR were carried out in 133 male idiopathic infertile patients for chromosome karyotype and Y chromosome microdeletion analysis.
RESULTS
Of the 133 patients, 25 (18.80%) were found to have chromosome abnormalities, and 12 (9.02%) were found to have Y chromosome microdeletions including 2 with varicocele and 2 with cryptorchism. Four patients had both chromosomal abnormalities and Y chromosome microdeletions.
CONCLUSION
The chromosomal abnormalities and Y chromosome microdeletions may play an important role in idiopathic male infertility, suggesting the importance of examinations of chromosomal abnormalities and Y chromosome microdeletions in such patients.
目的
探讨特发性男性不育患者染色体异常与Y染色体微缺失之间的关系。
方法
对133例特发性男性不育患者进行染色体核型分析及聚合酶链反应（PCR），以分析染色体核型和Y染色体微缺失情况。
结果
133例患者中，25例（18.80%）存在染色体异常，12例（9.02%）存在Y染色体微缺失，其中2例合并精索静脉曲张，2例合并隐睾。4例患者同时存在染色体异常和Y染色体微缺失。
结论
染色体异常和Y染色体微缺失可能在特发性男性不育中起重要作用，提示对此类患者进行染色体异常和Y染色体微缺失检查的重要性。
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