Passowicz-Muszyńska Ewa, Gostkowska-Malec Anna, Jankowska Renata, Piesiak Paweł
Pneumonol Alergol Pol. 2010;78(1):28-32.
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Patients with COPD are at increased risk of cardiovascular diseases, osteoporosis and lung cancer. Although some of the associations between COPD and atherosclerosis may be the result of common risk factors such as smoking, epidemiological evidence suggest that impaired lung function is a risk factor for increased cardiovascular death, independent of tobacco use. This phenomenon may be related to common genetic predisposition for atherosclerosis and emphysema. Chronic obstructive pulmonary disease, like atherosclerosis, is a disease of systemic inflammation and may hasten the progression of atherosclerosis and contribute to the higher rate of death in COPD. This article reviews close relationship between COPD and cardiovascular diseases, mainly atherosclerosis. The authors also present some preliminary data suggesting a possible influence of statin therapy on the clinical course of COPD.
慢性阻塞性肺疾病(COPD)是全球发病和死亡的主要原因。COPD患者患心血管疾病、骨质疏松症和肺癌的风险增加。虽然COPD与动脉粥样硬化之间的一些关联可能是吸烟等共同危险因素所致,但流行病学证据表明,肺功能受损是心血管死亡增加的危险因素,与吸烟无关。这种现象可能与动脉粥样硬化和肺气肿的共同遗传易感性有关。慢性阻塞性肺疾病与动脉粥样硬化一样,是一种全身性炎症性疾病,可能会加速动脉粥样硬化的进展,并导致COPD患者死亡率升高。本文综述了COPD与心血管疾病,主要是动脉粥样硬化之间的密切关系。作者还提供了一些初步数据,表明他汀类药物治疗可能对COPD的临床病程产生影响。