Chromatography and Separation Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Electrophoresis. 2010 Jan;31(4):695-701. doi: 10.1002/elps.200900486.
Retention index (I), rather than retention factor (k), was found to be a more reasonable parameter for comparison of the relative affinity of disubstituted benzenes in MEEKC and MEKC, due to independent of I with the SDS surfactant concentration. MEKC and MEEKC may give similar or different I values, depending on types of moieties. With known I and K(ow) for alkylbenzenes as references in MEKC and MEEKC, the values of K(ow) for disubstituted benzenes can be estimated from the observed I values, where K(ow) is the octanol-water distribution constant. In addition, a group additive approach can be used to predict I for disubstituted benzenes with different moieties from the average observed I for the disubstituted benzenes with same moieties. However, electronic effects and/or intramolecular interaction may result in the different observed I from prediction.
保留指数（I）而非保留因子（k）被发现是比较 MEKC 和 MEEKC 中二取代苯相对亲合力的更合理参数，因为 I 独立于 SDS 表面活性剂浓度。MEKC 和 MEEKC 可能给出相似或不同的 I 值，这取决于取代基的类型。在 MEKC 和 MEEKC 中，以烷基苯的已知 I 和 Kow 作为参考，可根据观察到的 I 值估算二取代苯的 Kow 值，其中 Kow 是辛醇-水分配常数。此外，可使用基团加和法，根据具有相同取代基的二取代苯的平均观察到的 I 值，预测具有不同取代基的二取代苯的 I 值。然而，电子效应和/或分子内相互作用可能导致观察到的 I 值与预测值不同。
