Istanbul University, Cerrahpasa Medical School, Department of General Surgery, Istanbul, Turkey.
Breast. 2010 Jun;19(3):226-30. doi: 10.1016/j.breast.2010.01.017. Epub 2010 Feb 18.
Although radioguided occult lesion localization (ROLL) has become a widely accepted technique, the optimal time interval between the radioisotope injection and surgery has not yet been determined.
To delineate the effects of time from the injection of the radionuclide until surgery on the ROLL success rate in a patient population diagnosed as having non-palpable breast cancer.
Between December 2004 and May 2009, 75 patients underwent ROLL procedure. The day-before protocol and same-day protocols included 50 and 25 breast cancer patients respectively.
The two study groups were comparable in terms of age, localization technique, radiological findings and the type of surgical procedures (P > 0.05). No statistically significant difference was noticed in the pathological diagnosis, cancer size and the surgical margin clearance between the two groups (P > 0.05).
Same-day injection of the radiotracer was not superior to the day-before injection in ROLL. The day-before protocol can be scheduled for the convenience of both patients and hospital staff.
虽然放射性核素引导的隐匿性病灶定位（ROLL）已成为一种广泛接受的技术，但尚未确定放射性核素注射与手术之间的最佳时间间隔。
描述在诊断为非可触及性乳腺癌的患者人群中，从放射性核素注射到手术的时间对 ROLL 成功率的影响。
在 2004 年 12 月至 2009 年 5 月期间，75 名患者接受了 ROLL 手术。前日方案和同日方案分别包括 50 例和 25 例乳腺癌患者。
两组在年龄、定位技术、影像学发现和手术类型方面具有可比性（P>0.05）。两组在病理诊断、癌症大小和手术切缘清除方面无统计学差异（P>0.05）。
同日注射放射性示踪剂并不优于前日注射 ROLL。前日方案可以根据患者和医院工作人员的方便进行安排。
