趋化因子及其受体：癌症相关炎症的新认识。
Chemokines and chemokine receptors: new insights into cancer-related inflammation.
机构信息
INSERM, U844, Site Saint Eloi - Bâtiment INM - 80 rue Augustin Fliche, University of Montpellier I, Montpellier, F-34090, France.
出版信息
Trends Mol Med. 2010 Mar;16(3):133-44. doi: 10.1016/j.molmed.2010.01.003. Epub 2010 Feb 15.
Abstract
Chemokines are involved in cellular interactions and tropism in situations frequently associated with inflammation. Recently, the importance of chemokines and chemokine receptors in inflammation associated with carcinogenesis has been highlighted. Increasing evidence suggests that chemokines are produced by tumor cells as well as by cells of the tumor microenvironment including cancer-associated fibroblasts (CAFs), mesenchymal stem cells (MSCs), endothelial cells, tumor-associated macrophages (TAMs) and more recently tumor-associated neutrophils (TANs). In addition to affecting tumor cell proliferation, angiogenesis and metastasis, chemokines also seem to modulate senescence and cell survival. Here, we review recent progress on the roles of chemokines and chemokine receptors in cancer-related inflammation, and discuss the mechanisms underlying chemokine action in cancer that might facilitate the development of novel therapies in the future.
摘要
趋化因子参与细胞间相互作用和趋向性，这些作用和趋向性通常与炎症有关。最近，趋化因子及其趋化因子受体在与癌症发生相关的炎症中的重要性得到了强调。越来越多的证据表明，趋化因子不仅由肿瘤细胞产生，也由肿瘤微环境中的细胞产生，包括癌相关成纤维细胞（CAFs）、间充质干细胞（MSCs）、内皮细胞、肿瘤相关巨噬细胞（TAMs），最近还有肿瘤相关中性粒细胞（TANs）。趋化因子除了影响肿瘤细胞的增殖、血管生成和转移外，似乎还调节衰老和细胞存活。在这里，我们综述了趋化因子及其趋化因子受体在癌症相关炎症中的作用的最新进展，并讨论了趋化因子在癌症中作用的机制，这可能有助于未来开发新的治疗方法。
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