Department of Microbiology and Immunology, University of Melbourne, Gate 11, Royal Parade, Parkville 3010, Victoria, Australia. E-mail address:
J Immunol. 2010 Mar 1;184(5):2237-42. doi: 10.4049/jimmunol.0902871.
Given the central role of intestinal dendritic cells (DCs) in the regulation of gut immune responses, it is not surprising that several bacterial pathogens have evolved strategies to prevent or bypass recognition by DCs. In this article, we will review recent findings on the interaction between intestinal DCs and prototypical bacterial pathogens, such as Salmonella, Yersinia, or Helicobacter. We will discuss the different approaches with which these pathogens seek to evade DC recognition and subsequent T cell activation. These diverse strategies span to include mounting irrelevant immune responses, inhibition of Ag presentation by DCs, and stretch as far as to manipulate the Th1/Th2 balance of CD4(+) T cells in the bacteria's favor.
鉴于肠道树突状细胞（DCs）在调节肠道免疫反应中的核心作用，几种细菌病原体已经进化出防止或绕过 DC 识别的策略也就不足为奇了。在本文中，我们将回顾肠道 DCs 与典型的细菌病原体（如沙门氏菌、耶尔森菌或幽门螺杆菌）之间相互作用的最新发现。我们将讨论这些病原体试图逃避 DC 识别和随后 T 细胞激活的不同方法。这些不同的策略包括引发无关的免疫反应、抑制 DC 抗原呈递，甚至操纵 CD4+T 细胞的 Th1/Th2 平衡，以有利于细菌。
