Jeong You Jeong, Lee Dong Ho, Choi Tae Hyuck, Hwang Tae Jun, Lee Byeong Hwan, Nah Jong Chon, Lee Sang Hyub, Park Young Soo, Hwang Jin-Hyok, Kim Jin-Wook, Jeong Sook-Hyang, Kim Nayoung, Jung Hyun Chae, Song In Sung
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Korean J Gastroenterol. 2010 Feb;55(2):100-8. doi: 10.4166/kjg.2010.55.2.100.
BACKGROUND/AIMS: Gastro-esophageal reflux disease (GERD) is a chronic condition, with 50-80% of patients experiencing recurrence within one year following completion of initial treatment. The present study aimed to estimate recurrence rate and treatment response in GERD patients treated with proton pump inhibitor.
A total of 207 symptomatic GERD patients, which were confirmed by endoscopy from July 2008 till January 2009, were enrolled. They were divided into non-erosive reflux disease (NERD) group and erosive reflux disease (ERD) group by endoscopic findings. Patients were treated with lansoprazole 15 mg (NERD group) or 30 mg (ERD group) once daily for 8 weeks. The presence of symptoms was assessed in each patient at baseline and post-treatment using a questionnaire. Subsequent symptomatic recurrence on the cessation of therapy in each improved patients was checked by telephone survey or outpatient interview.
Ninety-four patients and 113 patients were first diagnosed with NERD and ERD, respectively. The mean post-treatment follow-up period was 24.4+/-8.5 weeks. Recurrence rate was 40.0% (NERD, 43.8%; ERD, 37.1% (p=0.224)). Recurrence time was 10.1+/-5.8 weeks (NERD 9.6 weeks; ERD, 10.6 weeks (p=0.444)). Regarding the symptom improvement after 8 week therapy with lansoprazole, 89.4% (NERD, 85.1%; ERD, 92.9% (p=0.056)) of total patients were symptomatically improved.
Forty percentage of GERD patients recurred within 6 months following the completion of 8 week therapy with lansoprazole. Recurrence rate, recurrence time, and rate of symptom improvement were not significantly different between NERD group treated with half dose and ERD group treated with full dose lansoprazole.
背景/目的：胃食管反流病（GERD）是一种慢性病，50% - 80%的患者在初始治疗结束后的一年内会复发。本研究旨在评估接受质子泵抑制剂治疗的GERD患者的复发率及治疗反应。
纳入2008年7月至2009年1月间经内镜检查确诊的207例有症状的GERD患者。根据内镜检查结果将其分为非糜烂性反流病（NERD）组和糜烂性反流病（ERD）组。患者分别接受每日15毫克兰索拉唑（NERD组）或30毫克兰索拉唑（ERD组）治疗，疗程8周。在基线期和治疗后，通过问卷调查评估每位患者的症状情况。对每位症状改善的患者，在治疗停止后，通过电话调查或门诊随访检查症状复发情况。
分别有94例和113例患者首次被诊断为NERD和ERD。治疗后的平均随访期为24.4±8.5周。复发率为40.0%（NERD为43.8%；ERD为37.1%，p = 0.224）。复发时间为10.1±5.8周（NERD为9.6周；ERD为10.6周，p = 0.444）。关于兰索拉唑治疗8周后的症状改善情况，89.4%的患者（NERD为85.1%；ERD为92.9%，p = 0.056）症状得到改善。
8周兰索拉唑治疗结束后的6个月内，40%的GERD患者复发。半量兰索拉唑治疗的NERD组与全量兰索拉唑治疗的ERD组在复发率、复发时间及症状改善率方面无显著差异。
