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[老年患者化疗的机遇与局限]

[Chances and limitations of chemotherapy in elderly patients].

作者信息

Wedding U

机构信息

Klinik für Innere Medizin II, Abteilung Palliativmedizin, Universitätsklinikum Jena, Jena, Deutschland.

出版信息

Internist (Berl). 2010 Mar;51(3):402, 404-6, 408-9. doi: 10.1007/s00108-010-2601-x.

Abstract

The chronological age of a patient should not be a barrier to apply chemotherapy. Elderly patients can benefit from chemotherapy. Chronological age should not be a reason for diagnostic or therapeutic nihilism, as the age of a patient poorly characterizes their health situation. Data with high level of evidence on treatment of elderly patients with cancer are limited. A comprehensive geriatric assessment (CGA) describes the individual deficits and resources of a patient much better. Limitations in CGA are risk factors for increased toxicity and decreased treatment benefit. The currently available data demonstrate under- and over-treatment in elderly patients with cancer.

摘要

患者的实际年龄不应成为应用化疗的障碍。老年患者能够从化疗中获益。实际年龄不应成为诊断或治疗虚无主义的理由,因为患者的年龄并不能很好地反映其健康状况。关于老年癌症患者治疗的高质量证据数据有限。全面老年评估(CGA)能更好地描述患者的个体缺陷和资源。CGA的局限性是毒性增加和治疗获益降低的风险因素。目前可得的数据表明老年癌症患者存在治疗不足和过度治疗的情况。

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