Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
J Neurosci Methods. 2010 May 15;188(2):219-25. doi: 10.1016/j.jneumeth.2010.02.011. Epub 2010 Feb 17.
The CANTAB (Cambridge Neuropsychological Test Automated Battery), a system developed for human neuropsychological testing, has previously been used to assess cognitive function in two species of nonhuman primates, common marmoset monkeys and rhesus macaques. We describe the application of the system to the juvenile baboon, a nonhuman primate species offering specific investigative advantages. Juvenile baboons were trained and tested on a progressive ratio task to assess motivation, simple discrimination and simple reversal tasks to assess associative learning, and intra- and extra-dimensional set-shifting tasks to assess selective attention and attentional set-shifting, respectively. Study subjects were 8 juvenile baboons (Papio sp.), 4 females and 4 males aged 3.0+/-0.1 (mean+SEM) years and weight 8.2+/-0.4 kg. All baboons were easily trained, readily learned the neuropsychological tests and exhibited a stable performance. Applying a method such as the CANTAB has significant implications for expanding on the translational utility of the baboon in studies of neurodevelopment.
CANTAB（剑桥神经心理测试自动电池）是一种用于人类神经心理测试的系统，此前已被用于评估两种非人类灵长类动物，普通狨猴和恒河猴的认知功能。我们描述了该系统在幼年狒狒中的应用，这种非人类灵长类动物具有特定的研究优势。对 8 只幼年狒狒（Papio sp.），4 只雌性和 4 只雄性，年龄 3.0+/-0.1（平均值+SEM）岁，体重 8.2+/-0.4kg 进行了训练和测试，以评估动机，简单辨别和简单反转任务以评估联想学习，以及内在和外在维度的转移任务分别评估选择性注意力和注意力转移。所有狒狒都很容易训练，很容易学习神经心理学测试，并表现出稳定的表现。应用 CANTAB 等方法对于扩大狒狒在神经发育研究中的转化应用具有重要意义。
