University of Medicine and Pharmacy, C. Davila, Bucharest, Romania.
Best Pract Res Clin Obstet Gynaecol. 2010 Feb;24(1):81-6. doi: 10.1016/j.bpobgyn.2009.08.008.
Breast cancer is the most frequently occurring cancer in women of developed countries, and as a result of new developments in breast cancer treatment, more women are cured after being diagnosed with this disease. It is important that fertility preservation strategies are addressed before chemotherapy, because chemotherapy may induce premature ovarian failure (depending on the woman's age, the drugs used, the dosage and duration of treatment). Among possible solutions are embryos or oocytes cryopreservation, ovarian tissue cryopreservation-freezing with a subsequent orthotopic and heterotopic autotransplantation, whole ovary cryopreservation, ovarian suppression with gonadotropin-releasing hormone (GnRH) analogues, which inhibit ovarian follicular depletion induced by chemotherapeutic agents and in vitro fertilisation (IVF) after ovulation induction with aromatase inhibitors or tamoxifen.
乳腺癌是发达国家女性中最常见的癌症，由于乳腺癌治疗的新进展，更多的女性在被诊断出患有这种疾病后得到治愈。在化疗之前，关注生育力保存策略非常重要，因为化疗可能会导致卵巢早衰（取决于女性的年龄、使用的药物、剂量和治疗持续时间）。可能的解决方案包括胚胎或卵母细胞冷冻保存、卵巢组织冷冻保存-随后进行原位和异位自体移植、整个卵巢冷冻保存、使用促性腺激素释放激素（GnRH）类似物抑制卵巢卵泡耗竭，这种方法可抑制化疗药物引起的卵泡耗竭，还可在使用芳香化酶抑制剂或他莫昔芬诱导排卵后进行体外受精（IVF）。
