Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children's Hospital, Houston, TX, USA.
Curr Opin Immunol. 2010 Apr;22(2):251-7. doi: 10.1016/j.coi.2010.01.020. Epub 2010 Feb 17.
Adoptive transfer of T cells specific for antigens expressed on tumor cells is an attractive strategy for producing targeted and long-lived anti-tumor activity. T cell therapies have shown activity in selected clinical applications but broader application is limited by inadequate persistence of transferred T cells and by tumor-evasion strategies. Current research focuses on defining the optimum type of cell for transfer, genetically modifying infused T cells to augment function and overcome tumor evasion strategies and modulating the host environment.
过继转输针对肿瘤细胞表面抗原的 T 细胞是产生靶向和长效抗肿瘤活性的一种有吸引力的策略。T 细胞疗法在一些临床应用中显示出活性，但由于转输 T 细胞的持续时间不足和肿瘤逃避策略的限制，其广泛应用受到限制。目前的研究重点是确定最佳的细胞类型进行转输，通过基因修饰输注的 T 细胞来增强功能并克服肿瘤逃避策略，以及调节宿主环境。
