3q26 染色体区域的扩增对 LSIL 细胞学发现的非恶性转化具有高阴性预测值。
Amplification of the chromosome 3q26 region shows high negative predictive value for nonmalignant transformation of LSIL cytologic finding.
机构信息
Ikonisys Inc, New Haven, CT, USA.
出版信息
Am J Obstet Gynecol. 2010 Jun;202(6):581.e1-5. doi: 10.1016/j.ajog.2009.12.016. Epub 2010 Feb 20.
OBJECTIVE
The chromosome 3q26 region is a biomarker for cervical cancer. Women with low-grade squamous intraepithelial lesions (LSIL) currently are referred for immediate colposcopy. The objective of this study was to determine the negative predictive value of the 3q26 amplification test for the persistence or regression of LSIL.
STUDY DESIGN
Archival thin layer cytologic slides of 47 women (14-67 years old) with LSIL were linked to histologic and cytologic end points. To determine 3q status, the slides were hybridized for the chromosome 3q26 region and for the centromere of chromosome 7, as a control, with the use of the standard fluorescent in situ hybridization methods.
RESULTS
The negative predictive value of 3q26 gain for the development of cervical intraepithelial neoplasia grade 2/3 within 1 year was 93% (95% confidence interval, 68- 100); after 21 months, its negative predictive value was 100% (95% confidence interval, 29-100).
CONCLUSION
The 3q26 gain might help identify women with LSIL who do not need colposcopy.
目的
3 号染色体 q26 区域是宫颈癌的生物标志物。目前，低度鳞状上皮内病变（LSIL）的女性需要立即行阴道镜检查。本研究的目的是确定 3q26 扩增试验对 LSIL 持续或消退的阴性预测值。
研究设计
对 47 名（14-67 岁）LSIL 女性的存档薄层细胞学涂片与组织学和细胞学终点相关联。为了确定 3q 状态，使用标准荧光原位杂交方法对 3q26 区域和 7 号染色体着丝粒进行杂交，作为对照。
结果
3q26 增益在 1 年内发展为宫颈上皮内瘤变 2/3 的阴性预测值为 93%（95%置信区间，68-100）；21 个月后，其阴性预测值为 100%（95%置信区间，29-100）。
结论
3q26 增益可能有助于识别不需要阴道镜检查的 LSIL 女性。
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