Ruiz P, Tryphonopoulos P, Island E, Selvaggi G, Nishida S, Moon J, Berlanga A, Defranc T, Levi D, Tekin A, Tzakis A G
Department of Surgery, University of Miami School of Medicine, Miami, Florida, USA.
Transplant Proc. 2010 Jan-Feb;42(1):54-6. doi: 10.1016/j.transproceed.2009.12.029.
The purpose of this study was to evaluate the correlation of plasma citrulline and rejection episodes in intestinal transplantation.
From January 2007 until present, we performed citrulline assays on our small bowel patients. We investigated the correlation of these assays with the rejection status of the patients. The rejection status of the graft was defined based on graft biopsies.
Of 5195 citrulline samples, average serum citrulline levels decreased significantly when the patients presented a rejection episode. We found the following: no rejection, 17.38 microm/L; mild rejection, 13.05 microm/L; moderate rejection, 7.98 microm/L; and severe rejection, 6.05 microm/L. Our current emphasis is to determine the predictive power of citrulline with other biomarkers versus as a separate and isolated measurement.
In our study, citrulline levels correlated significantly with the rejection status of the graft. Serial follow-up of the patients using this assay may alert us to the possibility of increased alloreactivity and rejection episodes.
本研究的目的是评估血浆瓜氨酸与肠道移植排斥反应发作之间的相关性。
从2007年1月至今，我们对小肠移植患者进行了瓜氨酸检测。我们研究了这些检测结果与患者排斥反应状态之间的相关性。移植物的排斥反应状态基于移植物活检来定义。
在5195份瓜氨酸样本中，当患者出现排斥反应发作时，血清瓜氨酸平均水平显著下降。我们发现以下结果：无排斥反应时为17.38微摩尔/升；轻度排斥反应时为13.05微摩尔/升；中度排斥反应时为7.98微摩尔/升；重度排斥反应时为6.05微摩尔/升。我们目前的重点是确定瓜氨酸与其他生物标志物相比作为单独和孤立测量时的预测能力。
在我们的研究中，瓜氨酸水平与移植物的排斥反应状态显著相关。使用该检测方法对患者进行连续随访可能会提醒我们注意同种异体反应性增加和排斥反应发作的可能性。
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