Department of Otorhinolaryngology, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY, USA.
Otolaryngol Head Neck Surg. 2010 Mar;142(3):327-31. doi: 10.1016/j.otohns.2009.12.020.
Large dural defects after extended endoscopic endonasal skull base resections require meticulous reconstruction to prevent a cerebrospinal fluid leak postoperatively. The nasoseptal flap is a vascularized tissue graft developed to aid in the multilayer reconstruction of the skull base. The purpose of this study is to describe the first experiences with bilateral nasoseptal flaps for reconstruction of very large skull base defects.
Prospective, observational study.
Large tertiary referral center (New York Presbyterian Hospital).
Five patients underwent a multilayer reconstruction after an extended endoscopic transsphenoidal skull base surgery that included bilateral nasoseptal flaps. Pathologies consisted of two pituitary macroadenomas, one planum sphenoidale meningioma, one craniopharyngioma, and one cavernous sinus hemangioma.
All five patients underwent successful skull base reconstruction without a cerebrospinal fluid leak, complication at the reconstruction site, or anterior extension of the posterior septal perforation.
Bilateral nasoseptal flaps are a viable option for large dural defects of the anterior and ventral skull base when one nasoseptal flap may not completely seal the entire defect.
扩大经鼻内镜颅底切除术后面部有较大的颅骨缺损,需要精心重建,以防止术后发生脑脊液漏。鼻中隔黏膜瓣是一种带血管组织移植物,用于帮助颅底的多层重建。本研究的目的是描述双侧鼻中隔黏膜瓣用于重建非常大的颅底缺陷的首次经验。
前瞻性、观察性研究。
大型三级转诊中心(纽约长老会医院)。
5 例患者在接受经鼻内镜颅底扩大手术后,采用多层重建,包括双侧鼻中隔黏膜瓣。病变包括 2 例垂体大腺瘤、1 例蝶骨嵴脑膜瘤、1 例颅咽管瘤和 1 例海绵窦血管瘤。
所有 5 例患者均成功进行了颅底重建,无脑脊液漏、重建部位并发症或后鼻中隔穿孔向前延伸。
当单侧鼻中隔黏膜瓣不能完全封闭整个缺陷时,双侧鼻中隔黏膜瓣是前颅底和前颅底大硬脑膜缺损的可行选择。