Menin 在骨骼发育中的作用。
Role of menin in bone development.
机构信息
Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
出版信息
Adv Exp Med Biol. 2009;668:59-67. doi: 10.1007/978-1-4419-1664-8_6.
Menin function is related to transcriptional regulation and cell cycle control and it physically and functionally interacts with osteotropic transcription factors, such as Smad1/5, Smad3, Runx2 and JunD. Menin promotes the commitment of pluripotent mesenchymal stem cells to the osteoblast lineage, mediated by interactions between menin and the BMP signaling molecules, Smad1/5, or Runx2. On the other hand, in mature osteoblasts the interaction of menin and the TGF-beta/Smad3 pathway counteracts the BMP-2/Smad1/5- and Runx2-induced transcriptional activities leading to inhibition of late stage osteoblast differentiation. Moreover, menin suppresses osteoblast maturation partly by inhibiting the differentiation actions of JunD. In conclusion, menin plays an important role in osteoblastogenesis and osteoblast differentiation.
Menin 的功能与转录调控和细胞周期控制有关，它与成骨转录因子（如 Smad1/5、Smad3、Runx2 和 JunD）在物理和功能上相互作用。Menin 通过与 BMP 信号分子 Smad1/5 或 Runx2 的相互作用，促进多能间充质干细胞向成骨细胞系的定向分化。另一方面，在成熟的成骨细胞中，menin 与 TGF-β/Smad3 通路的相互作用拮抗了 BMP-2/Smad1/5-和 Runx2 诱导的转录活性，从而抑制晚期成骨细胞分化。此外，menin 通过抑制 JunD 的分化作用，部分抑制成骨细胞的成熟。总之，menin 在成骨细胞发生和分化中发挥重要作用。
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