Clarke Loren E, Frauenhoffer Elizabeth, Fox Edward, Neves Rogerio, Bruggeman Richard D, Helm Klaus F
Department of Pathology, Penn State Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA.
J Cutan Pathol. 2010 Jul;37(7):737-43. doi: 10.1111/j.1600-0560.2010.01532.x. Epub 2010 Feb 18.
CD10 is now commonly used to differentiate atypical fibroxanthoma (AFX) from melanoma, spindle cell and dedifferentiated variants of squamous cell carcinoma and leiomyosarcoma. However, we have encountered CD10-positive tumors that mimicked AFX but proved to be myxofibrosarcomas. The purpose of this study was to evaluate CD10 expression in a wide range of mesenchymal neoplasms that may involve the skin using tissue microarrays. Our results indicate that in addition to AFX, CD10 expression is common in myxofibrosarcomas, undifferentiated pleomorphic sarcomas, dermatofibromas and dermatofibrosarcoma protuberans. Myxofibrosarcomas commonly present in the skin and may be difficult to distinguish from AFX on small biopsies and CD10 positivity may confound the diagnostic difficulty.
CD10目前常用于鉴别非典型纤维黄色瘤（AFX）与黑色素瘤、鳞状细胞癌和平滑肌肉瘤的梭形细胞及去分化型变体。然而，我们遇到过一些CD10阳性的肿瘤，它们酷似AFX，但最终证实是黏液纤维肉瘤。本研究的目的是利用组织微阵列评估一系列可能累及皮肤的间叶性肿瘤中CD10的表达情况。我们的结果表明，除AFX外，CD10在黏液纤维肉瘤、未分化多形性肉瘤、皮肤纤维瘤和隆突性皮肤纤维肉瘤中也普遍表达。黏液纤维肉瘤常见于皮肤，在小活检标本上可能难以与AFX区分，而CD10阳性可能会增加诊断难度。
