Maternal and Fetal Research Unit, Division of Reproduction and Endocrinology, King's College London School of Biomedical and Health Sciences, London, UK.
BJOG. 2010 May;117(6):695-700. doi: 10.1111/j.1471-0528.2010.02507.x. Epub 2010 Feb 22.
To evaluate the clinical and geographical variation in the use of aspirin in women at high risk of pre-eclampsia, and in the use of antihypertensive drugs and magnesium sulphate in women with established pre-eclampsia.
Analysis of vitamins in pre-eclampsia (VIP) trial database.
A total of 2399 women at increased risk of pre-eclampsia in 25 UK hospitals.
An analysis of a large prospectively validated database of high-risk women in the UK was undertaken to assess aspirin use across different risk groups and to evaluate the use of antihypertensives and magnesium sulphate in 370 women who developed pre-eclampsia. Logistic regression was employed to compare drug use between region and by recognised clinical indicators.
Usage of aspirin, antihypertensive drugs and magnesium sulphate.
Of the women with known risk factors at trial entry, 24% (569/2399) received low-dose aspirin. Aspirin usage varied widely between risk groups [from 5% (19/378) in women with multiple pregnancy to 94% (50/53) in women with antiphospholipid syndrome] and between geographical regions [from 8% (20/248) to 49% (95/193)]. Three hundred and seventy women developed pre-eclampsia, 52% (n = 193) of whom received new or additional antihypertensives after 20 weeks of gestation; 34% (77/224) with a maximum recorded systolic blood pressure of >OR=160 mmHg in the second half of pregnancy did not receive antihypertensive treatment; 17% (62/370) of women with pre-eclampsia received magnesium sulphate prophylactically.
Prophylactic and treatment regimes for pre-eclampsia in the UK vary by region and risk group.
评估在英国高风险子痫前期妇女中使用阿司匹林的临床和地理变化，以及在已确诊子痫前期妇女中使用抗高血压药物和硫酸镁的情况。
分析子痫前期维生素（VIP）试验数据库。
英国 25 家医院的 2399 名子痫前期高危妇女。
对英国高危妇女的大型前瞻性验证数据库进行分析，以评估不同风险组中阿司匹林的使用情况，并评估 370 名发生子痫前期妇女的抗高血压药物和硫酸镁的使用情况。采用逻辑回归比较不同地区和公认的临床指标之间的药物使用情况。
阿司匹林、抗高血压药物和硫酸镁的使用情况。
在试验开始时有已知危险因素的妇女中，24%（569/2399）接受了低剂量阿司匹林。阿司匹林的使用在不同风险组之间差异很大[从多胎妊娠的 5%（19/378）到抗磷脂抗体综合征的 94%（50/53）]，在不同地理区域之间也存在差异[从 8%（20/248）到 49%（95/193）]。有 370 名妇女发生了子痫前期，其中 52%（n=193）在妊娠 20 周后接受了新的或额外的抗高血压药物治疗；34%（77/224）在妊娠后半期收缩压>或=160mmHg的最大记录值的妇女未接受抗高血压治疗；17%（62/370）的子痫前期妇女预防性接受了硫酸镁治疗。
英国子痫前期的预防和治疗方案因地区和风险组而异。
