Maldonado R
Laboratori de Neurofarmacologia, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Espagne.
Ann Pharm Fr. 2010 Jan;68(1):3-11. doi: 10.1016/j.pharma.2009.12.001. Epub 2010 Jan 21.
Drug addiction is a chronic brain disorder leading to complex adaptive changes within the brain reward circuits. Several neurotransmitters, including the endogenous opioid system are involved in these changes. The opioid system plays a pivotal role in different aspects of addiction. Thus, opioid receptors and endogenous opioid peptides are largely distributed in the mesolimbic system and modulate dopaminergic activity within the reward circuits. Opioid receptors and peptides are selectively involved in several components of the addictive processes induced by opioids, cannabinoids, psychostimulants, alcohol and nicotine. This review is focused on the contribution of each component of the endogenous opioid system in the addictive properties of the different drugs of abuse.
药物成瘾是一种慢性脑部疾病，会导致大脑奖赏回路发生复杂的适应性变化。包括内源性阿片系统在内的几种神经递质参与了这些变化。阿片系统在成瘾的不同方面起着关键作用。因此，阿片受体和内源性阿片肽广泛分布于中脑边缘系统，并调节奖赏回路中的多巴胺能活动。阿片受体和肽选择性地参与由阿片类药物、大麻素、精神兴奋剂、酒精和尼古丁引起的成瘾过程的几个组成部分。本综述聚焦于内源性阿片系统各组成部分在不同滥用药物成瘾特性中的作用。
