Kim Jin Hwi, Choi Young Jin, Kim Dong Chul, Lee Sung Jong
Department of Obstetrics and Gynecology, Catholic University, Seoul, Korea.
J Obstet Gynaecol Res. 2010 Feb;36(1):187-90. doi: 10.1111/j.1447-0756.2009.01117.x.
Mitotically active leiomyomas exhibiting insignificant cytologic atypia (none to mild) with an increased mitotic count of 5-20 mitotic figures per 10 high power fields, and without coagulative tumor cell necrosis or atypical mitoses, tend to have a benign clinical course. We encountered a case of a mitotically active leiomyoma and malignant transformation after a total hysterectomy. The recurrent multiple abdominal masses were removed surgically; most of them were benign leiomyomas, but some were leiomyosarcomas. Although most mitotically active leiomyomas have a benign clinical course, these lesions can recur and have the potential for malignant transformation. Therefore, patients with mitotically active leiomyomas require close follow-up.
有丝分裂活跃的平滑肌瘤，细胞学异型性不明显（无至轻度），有丝分裂计数增加，每10个高倍视野有5 - 20个有丝分裂象，且无凝固性肿瘤细胞坏死或非典型有丝分裂，往往具有良性临床病程。我们遇到一例有丝分裂活跃的平滑肌瘤在全子宫切除术后发生恶变的病例。复发性腹部多发肿块经手术切除；其中大多数是良性平滑肌瘤，但有些是平滑肌肉瘤。尽管大多数有丝分裂活跃的平滑肌瘤具有良性临床病程，但这些病变可能复发并有恶变的可能。因此，有丝分裂活跃的平滑肌瘤患者需要密切随访。
