Watanabe Noriko, Okita Hajime, Matsuoka Kentaro, Kiyotani Chikako, Fujii Eriko, Kumagai Masaaki, Nakagawa Atsuko
Division of Pathology, National Center for Child Health and Development, Tokyo, Japan.
J Obstet Gynaecol Res. 2010 Feb;36(1):213-6. doi: 10.1111/j.1447-0756.2009.01083.x.
Vaginal yolk sac (endodermal sinus) tumors were diagnosed in two girls (ages 12 and 46 months). In both, the only manifestation was persistent vaginal bleeding. Pelvic ultrasonography, computed tomography, and magnetic resonance imaging revealed solitary vaginal masses (diameter, 5 and 2 cm, respectively). Serum alpha-fetoprotein was highly elevated in one patient and normal in the other. Biopsy was performed in the first patient, and a tumor excision, in the second. Combination chemotherapy with cisplatin, etoposide, and bleomycin or carboplatin was administered to the first patient, and shortly thereafter, the tumor size decreased by more than half; serum alpha-fetoprotein was normalized after four chemotherapy cycles. After chemotherapy, magnetic resonance imaging revealed a small residual lesion, however the second biopsy revealed no viable tumor cells. In the second patient, no visible tumor was observed after chemotherapy by vaginoscopy. Both patients are well at 19 and 14 months after diagnosis, respectively.
两名女孩（年龄分别为12个月和46个月）被诊断出患有阴道卵黄囊瘤（内胚窦瘤）。两人的唯一表现均为持续性阴道出血。盆腔超声、计算机断层扫描和磁共振成像显示阴道内有单个肿块（直径分别为5厘米和2厘米）。一名患者血清甲胎蛋白高度升高，另一名患者正常。第一名患者进行了活检，第二名患者进行了肿瘤切除。第一名患者接受了顺铂、依托泊苷和博来霉素或卡铂的联合化疗，此后不久，肿瘤大小缩小了一半以上；四个化疗周期后血清甲胎蛋白恢复正常。化疗后，磁共振成像显示有一个小的残留病灶，但第二次活检未发现存活的肿瘤细胞。在第二名患者中，化疗后经阴道镜检查未观察到可见肿瘤。两名患者分别在诊断后19个月和14个月时情况良好。
