Kawai Takeshi, Watanabe Yutaka, Tonogi Morio, Yamane Gen-yuki, Abe Shinichi, Yamada Yoshiaki, Callan Akiko
Department of Oral Medicine, Oral and Maxillofacial Surgery, Tokyo Dental College, Ichikawa, Chiba, Japan.
Bull Tokyo Dent Coll. 2009;50(4):169-81. doi: 10.2209/tdcpublication.50.169.
We focused on brain areas activated by audiovisual stimuli related to swallowing motions. In this study, three kinds of stimuli related to human swallowing movement (auditory stimuli alone, visual stimuli alone, or audiovisual stimuli) were presented to the subjects, and activated brain areas were measured using fMRI and analyzed. When auditory stimuli alone were presented, the supplementary motor area was activated. When visual stimuli alone were presented, the premotor and primary motor areas of the left and right hemispheres and prefrontal area of the left hemisphere were activated. When audiovisual stimuli were presented, the prefrontal and premotor areas of the left and right hemispheres were activated. Activation of Broca's area, which would have been characteristic of mirror neuron system activation on presentation of motion images, was not observed; however, activation of brain areas related to swallowing motion programming and performance was verified for auditory, visual and audiovisual stimuli related to swallowing motion. These results suggest that audiovisual stimuli related to swallowing motion could be applied to the treatment of patients with dysphagia.
我们聚焦于与吞咽动作相关的视听刺激所激活的脑区。在本研究中，向受试者呈现了三种与人类吞咽运动相关的刺激（仅听觉刺激、仅视觉刺激或视听刺激），并使用功能磁共振成像（fMRI）测量并分析了激活的脑区。当仅呈现听觉刺激时，辅助运动区被激活。当仅呈现视觉刺激时，左右半球的运动前区和初级运动区以及左半球的前额叶区域被激活。当呈现视听刺激时，左右半球的前额叶和运动前区被激活。未观察到在呈现运动图像时本应具有镜像神经元系统激活特征的布洛卡区的激活；然而，对于与吞咽运动相关的听觉、视觉和视听刺激，与吞咽运动编程和执行相关的脑区的激活得到了证实。这些结果表明，与吞咽运动相关的视听刺激可应用于吞咽困难患者的治疗。
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