Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, CVK, Berlin, Germany.
Eat Weight Disord. 2009 Dec;14(4):e205-11. doi: 10.1007/BF03325118.
To compare general and eating disorder-specific psychopathology in patients with acute anorexia nervosa (acAN), weight-recovered patients (recAN) and healthy control women (HCW).
One hundred anorexia nervosa patients (66 acAN and 34 recAN) and 88 HCW were included in our study. Psychopathology was assessed by self-report questionnaires [Symptom Check List 90 Revised (SCL-90-R), Eating Disorder Inventory-2 (EDI- 2)] as well as by interview [Structured Interview of Anorexia Nervosa and Bulimic Syndromes (SIAB-EX)] and compared using multivariate analysis of variance. Plasma leptin levels were determined using enzyme linked immunosorbent assay.
Mean comparisons indicated highly significant differences between acAN and recAN subjects on all psychopatholgy variables, except for perfectionism. RecAN subjects did not differ from HCW. Partial weight recovery was associated with decreasing levels of psychopathology. Correlational analyses suggested strong negative associations between leptin levels and psychopathology.
Prolonged malnutrition, as indicated by suppressed plasma leptin levels, is strongly related to eating disorder-specific as well as general psychopathological symptoms. Weight recovery is associated with the absence of psychopathology. These data emphasize the interaction between somatic and psychological variables.
比较急性厌食症（acAN）患者、体重恢复患者（recAN）和健康对照组女性（HCW）的一般和特定于进食障碍的精神病理学。
我们的研究纳入了 100 名厌食症患者（66 名 acAN 和 34 名 recAN）和 88 名 HCW。精神病理学通过自我报告问卷[症状清单 90 修订版（SCL-90-R）、饮食障碍量表-2（EDI-2）]以及访谈[厌食症和贪食症综合征的结构化访谈（SIAB-EX）]进行评估，并使用多元方差分析进行比较。使用酶联免疫吸附测定法测定血浆瘦素水平。
均值比较表明，acAN 和 recAN 受试者在所有精神病理学变量上均存在高度显著差异，除了完美主义。recAN 受试者与 HCW 无差异。部分体重恢复与精神病理学水平降低有关。相关分析表明，瘦素水平与精神病理学之间存在强烈的负相关。
如血浆瘦素水平降低所表明的长期营养不良与特定于进食障碍和一般精神病理学症状密切相关。体重恢复与无精神病理学有关。这些数据强调了躯体和心理变量之间的相互作用。
