Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom.
Anesthesiology. 2010 Mar;112(3):729-41. doi: 10.1097/ALN.0b013e3181ca3179.
Pain originating in inflammation is the most common pathologic pain condition encountered by the anesthesiologist whether in the context of surgery, its aftermath, or in the practice of pain medicine. Inflammatory agents, released as components of the body's response to peripheral tissue damage or disease, are now known to be collectively capable of activating transient receptor potential vanilloid type 1, transient receptor potential vanilloid type 4, transient receptor potential ankyrin type 1, and acid-sensing ion channels, whereas individual agents may activate only certain of these ion channels. These ionotropic receptors serve many physiologic functions-as, indeed, do many of the inflammagens released in the inflammatory process. Here, we introduce the reader to the role of these ionotropic receptors in mediating peripheral pain in response to inflammation.
疼痛源于炎症，这是麻醉师在手术中、手术之后或在疼痛医学实践中最常遇到的病理性疼痛情况。现在已知，作为身体对周围组织损伤或疾病的反应的一部分而释放的炎症介质能够共同激活瞬时受体电位香草酸型 1、瞬时受体电位香草酸型 4、瞬时受体电位锚蛋白型 1 和酸敏离子通道，而个别介质可能仅激活这些离子通道中的某些。这些离子型受体具有许多生理功能——事实上，在炎症过程中释放的许多炎症介质也具有这些功能。在这里，我们向读者介绍这些离子型受体在介导外周炎症性疼痛中的作用。
