Wörmann B, Wolff J M
Hämatoonkologische Schwerpunktpraxis Bremen, Parkallee 41-45, 28209 Bremen.
Urologe A. 2010 Feb;49(2):221-7. doi: 10.1007/s00120-010-2238-3.
Systemic treatment of advanced prostate cancer is multifaceted. First-line therapy is antihormonal treatment with androgen deprivation or antiandrogens. Chemotherapy is effective in hormone refractory (castration resistant) prostate cancer. Alternative and supplementary options include radionuclides, steroids, and symptomatic measures. Use of bisphosphonates is standard in metastatic bone disease. Treatment of patients with metastatic prostate cancer is palliative. The aims are prolongation of overall survival, prolongation of progression-free survival, control and relief of symptoms, and restoration and maintenance of quality of life. Current options allow personalized patient care. New approaches and new drugs will increase the therapeutic possibilities considerably.
晚期前列腺癌的全身治疗是多方面的。一线治疗是采用雄激素剥夺或抗雄激素药物进行抗激素治疗。化疗对激素难治性（去势抵抗性）前列腺癌有效。替代和补充治疗方案包括放射性核素、类固醇和对症治疗措施。双膦酸盐的使用是转移性骨病的标准治疗方法。转移性前列腺癌患者的治疗是姑息性的。目标是延长总生存期、延长无进展生存期、控制和缓解症状，以及恢复和维持生活质量。目前的治疗方案允许进行个性化的患者护理。新的方法和新药将大大增加治疗的可能性。
