Department of Medical Laboratory Technology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
AIDS Res Ther. 2010 Jan 14;7:2. doi: 10.1186/1742-6405-7-2.
Adequate antiretroviral drug potency is essential for obtaining therapeutic benefit, however, the behavioral aspects of proper adherence and readiness to medication, often determine therapeutic outcome. Therefore, this study aimed to assess the level and determinants of nonadherence and nonreadiness to highly active antiretroviral therapy (HAART) among people living with HIV/AIDS (PLWHA) at Gondar University Teaching Hospital and Felege Hiwot Hospital in Northwest Ethiopia.
A cross-sectional study was conducted between July and September 2008 using structured interviewer-administered questionnaire. All consecutive adult outpatients who were receiving antiretroviral treatment for at least three months, seen at both hospitals during the study period and able to give informed consent were included in the study. Multivariate logistic regression was used to determine factors associated with nonadherence and nonreadiness.
A total of 504 study subjects were included in this study. The prevalence rates of nonadherence and nonreadiness to HAART were 87 (17.3%) and 70 (13.9%) respectively. Multivariate logistic regression analysis revealed that medication adverse effects, nonreadiness to HAART, contact with psychiatric care service and having no goal had statistically significant association with nonadherence. Moreover, unwillingness to disclose HIV status was significantly associated with nonreadiness to HAART.
In this study the level of nonadherence and nonreadiness to HAART seems to be encouraging. Several factors associated with nonadherance and nonreadiness to HAART were identified. Efforts to minimize nonadherence and nonreadiness to HAART should be integrated in to regular clinical follow up of patients.
获得治疗效益的关键在于抗逆转录病毒药物具有足够的效力，但适当的坚持治疗和对药物的准备情况等行为方面通常也会决定治疗结果。因此，本研究旨在评估埃塞俄比亚西北部贡德尔大学教学医院和 Felege Hiwot 医院的艾滋病毒/艾滋病（PLWHA）患者坚持使用高效抗逆转录病毒疗法（HAART）的水平和决定因素以及对 HAART 准备不足的情况。
这是一项 2008 年 7 月至 9 月进行的横断面研究，使用了结构式访谈员管理的问卷。所有连续接受抗逆转录病毒治疗至少三个月的成年门诊患者，在研究期间在这两家医院就诊并能够给予知情同意的患者都被纳入研究。采用多变量逻辑回归分析来确定与不坚持治疗和对 HAART 准备不足相关的因素。
本研究共纳入 504 名研究对象。HAART 不坚持治疗和对 HAART 准备不足的发生率分别为 87（17.3%）和 70（13.9%）。多变量逻辑回归分析显示，药物不良反应、对 HAART 准备不足、接触精神科护理服务和没有目标与不坚持治疗有统计学显著关联。此外，不愿透露 HIV 状况与对 HAART 准备不足有显著关联。
在这项研究中，HAART 不坚持治疗和对 HAART 准备不足的水平似乎令人鼓舞。确定了与不坚持治疗和对 HAART 准备不足相关的几个因素。应将减少不坚持治疗和对 HAART 准备不足的努力纳入患者的常规临床随访中。
