Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
J Psychiatr Res. 2010 Sep;44(12):741-7. doi: 10.1016/j.jpsychires.2010.02.003. Epub 2010 Feb 23.
The aim of this study was to estimate suicide risk during hospitalization and in the year following discharge for patients with mental disorders. All suicide cases in Sweden 18 years and older, between 1991 and 2003 (N=20,675; 70% male), were individually matched to 10 controls from the general Swedish population. Discharge diagnoses in the year before suicide of any mental disorder, mood disorder, schizophrenia spectrum disorder, and alcohol use disorder were identified from the Swedish Patient Register. Highest suicide risk during hospitalization and in the year following discharge was found for mood disorder [odds ratio (OR) 55 (95% CI, 47-65) for men and 86 (95% CI, 70-107) for women], with the risk peaking in the first week following discharge [OR 177 (95% CI, 78-401) for men and OR 268 (95% CI, 85-846) for women]. Compared to that for mood disorder, the suicide risk for schizophrenia spectrum disorder and alcohol use disorder was about half and more constant over time. The majority of suicide victims with a psychiatric diagnosis had been discharged from psychiatric treatment more than a month before the suicide. Over time, a constant proportion of 25% of the suicide victims had been hospitalized with a mental disorder in the year before suicide (23% of males and 31% of females), despite a significant decrease in psychiatric hospitalizations in the population. In conclusion, suicide risk was found to vary by type of mental disorder, time since discharge, and sex. This should be taken into account when planning suicide preventive efforts.
本研究旨在评估精神障碍患者住院期间和出院后一年内的自杀风险。在瑞典,1991 年至 2003 年间,对所有年龄在 18 岁及以上的自杀病例(70%为男性,共 20675 人)进行了个体匹配,匹配对象为来自一般瑞典人群的 10 名对照者。自杀前一年,从瑞典患者登记处确定了任何精神障碍、心境障碍、精神分裂症谱系障碍和酒精使用障碍的出院诊断。研究发现,心境障碍患者的住院期间和出院后一年内自杀风险最高[男性的比值比(OR)为 55(95%可信区间,47-65),女性为 86(95%可信区间,70-107)],出院后第一周风险最高[男性的 OR 为 177(95%可信区间,78-401),女性的 OR 为 268(95%可信区间,85-846)]。与心境障碍相比,精神分裂症谱系障碍和酒精使用障碍的自杀风险约为其一半,且随时间变化较为稳定。大多数有精神科诊断的自杀受害者在自杀前一个月以上已从精神科治疗中出院。随着时间的推移,在自杀前一年有精神障碍住院史的自杀受害者比例保持不变,为 25%(男性占 23%,女性占 31%),尽管人群中的精神科住院人数显著下降。总之,自杀风险因精神障碍类型、出院后时间和性别而异。在规划自杀预防工作时应考虑到这一点。