Department of Medicine, University at Buffalo, State University of New York, Infectious Diseases and HIV Medicine, Immunodeficiency Clinic, 462 Grider Street, Buffalo, NY 14215, USA.
J Clin Microbiol. 2010 May;48(5):1753-7. doi: 10.1128/JCM.01065-08. Epub 2010 Feb 24.
Staphylococcus aureus is the most common etiologic agent of skin abscesses. The regional rate of methicillin-resistant S. aureus (MRSA) abscesses may reflect the prevalence of local community-acquired MRSA (CAMRSA). A retrospective study was conducted to compare the antimicrobial susceptibility patterns of S. aureus isolates recovered from abscesses from 2003 to 2006 from patients at hospitals of the Kaleida Health System in western New York. S. aureus susceptibility information was obtained from a Vitek Legacy system, and the location and source of each isolate were identified. EpiInfo software was used to analyze the antimicrobial susceptibilities of all isolates and the trends in the rates of MRSA. A total of 2,848 S. aureus abscesses were identified by the Kaleida Health Clinical Microbiology Laboratory. Of those, 978 S. aureus abscess events occurred in four hospitals, including three adult facilities (547 episodes with 62 cases of bacteremia) and one children's facility (431 episodes with 2 cases of bacteremia). The MRSA rates in adults increased from 56% (2003) to 71% (2006), and that in children increased from 26% (2003) to 64% (2006). Of the MRSA isolates in the children's samples, more than 92% were susceptible to clindamycin. Of the MRSA isolates in the adult samples, 50% were susceptible to clindamycin in 2003 and 2004, whereas greater than 75% were susceptible in 2005 and 2006. The increased rates of MRSA abscesses with susceptibility to clindamycin may reflect the high prevalence level of CAMRSA in the western New York community. The variations in S. aureus susceptibilities could serve as an indicator of the changing resistance patterns within a broad urban community.
金黄色葡萄球菌是皮肤脓肿最常见的病原体。耐甲氧西林金黄色葡萄球菌（MRSA）脓肿的地区发生率可能反映了当地社区获得性耐甲氧西林金黄色葡萄球菌（CAMRSA）的流行情况。对 2003 年至 2006 年间，来自纽约西部 Kaleida 卫生系统医院的脓肿患者的金黄色葡萄球菌分离株的抗菌药物敏感性模式进行了回顾性研究。金黄色葡萄球菌的药敏信息来自 Vitek Legacy 系统，并且确定了每个分离株的位置和来源。使用 EpiInfo 软件分析了所有分离株的抗菌药物敏感性以及 MRSA 发生率的趋势。Kaleida 健康临床微生物学实验室共确定了 2848 例金黄色葡萄球菌脓肿。其中，978 例金黄色葡萄球菌脓肿事件发生在 4 家医院，包括 3 家成人医院（547 例，62 例菌血症）和 1 家儿童医院（431 例，2 例菌血症）。成人中的 MRSA 发生率从 2003 年的 56%增加到 2006 年的 71%，儿童中的 MRSA 发生率从 2003 年的 26%增加到 2006 年的 64%。儿童样本中的 MRSA 分离株中，超过 92%对克林霉素敏感。成人样本中的 MRSA 分离株中，2003 年和 2004 年有 50%对克林霉素敏感，而 2005 年和 2006 年有超过 75%的分离株敏感。对克林霉素敏感的 MRSA 脓肿的发生率增加可能反映了纽约西部社区中 CAMRSA 的高流行水平。金黄色葡萄球菌敏感性的变化可以作为广泛的城市社区内耐药模式变化的指标。
