Veterans Administration Connecticut Healthcare System, Clinical Epidemiology Research Center, West Haven, Connecticut 06516, USA.
Acad Med. 2010 Mar;85(3):548-55. doi: 10.1097/ACM.0b013e3181ccd83c.
Clinical decision making plays a crucial role in the transformation of science to service. Treatment decisions typically are evaluated by comparing them against norms, such as practice guidelines. An adherence standard has been criticized as inappropriate, but no measurable alternative has been proposed to date. This study develops a new standard of incorporation and a companion matching test, and addresses two questions: (1) Do clinicians incorporate a treatment guideline even when they do not endorse it? (2) If so, do they incorporate the guideline consistently?
The study uses the clinical paradigm of treatment-resistant schizophrenia and a published guideline developed at the Yale University Department of Psychiatry that has been soundly rejected in clinical practice. A vignette study was developed, using a four-factor, fully crossed and within-subject design, then administered to 21 volunteer paid psychiatry residents.
The endorsement pattern showed a low concurrence rate and significant apparent inconsistency within subjects. However, the matching test showed a clear relationship between endorsement of the guideline and features of individual vignettes. The matching test demonstrated significant within-subject consistency and accounted for 65% of the endorsement variance.
Implications are preliminary, given limitations that pertain to the subject population and use of vignettes, the clinical paradigm, and treatment guideline. However, the study's concepts, procedures, and findings may play a valuable role in future transformative initiatives, including training clinicians in the use of clinical guidelines and evaluating the appropriateness of guidelines before their implementation.
临床决策在将科学转化为服务方面起着至关重要的作用。治疗决策通常通过与规范(如实践指南)进行比较来进行评估。尽管已经批评了遵守标准不恰当,但迄今为止尚未提出可衡量的替代标准。本研究制定了一种新的纳入标准和配套的匹配测试,并回答了两个问题:(1)即使不认可治疗指南,临床医生是否也会采用该指南?(2)如果是这样,他们是否一致地采用该指南?
本研究采用治疗抵抗性精神分裂症的临床范例和耶鲁大学精神病学系制定的已在临床实践中被断然拒绝的已发表指南。开发了一个四因素、完全交叉和被试内设计的病例研究,并对 21 名志愿付费精神病学住院医师进行了研究。
认可模式显示出低一致性率和明显的明显不一致性。然而,匹配测试显示了指南认可与个体病例特征之间的明确关系。匹配测试显示出明显的被试内一致性,占认可变异的 65%。
鉴于研究对象人群、病例研究的使用、临床范例和治疗指南存在局限性,结果尚属初步。然而,该研究的概念、程序和发现可能在未来的变革性举措中发挥重要作用,包括培训临床医生使用临床指南以及在实施指南之前评估其适当性。