State Key Laboratory of Cancer Biology and Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Pathol Oncol Res. 2010 Jun;16(2):253-7. doi: 10.1007/s12253-009-9219-0. Epub 2009 Dec 11.
The aim of this study was to evaluate the expression of beta-catenin in astrocytoma, and the clinical relevance and prognostic significance of the expression of beta-catenin was also analyzed. Immunohistochemistry was performed on 63 resected astrocytoma tumor specimens to detect the expression of beta-catenin. The correlation between the results of immuoexpression and the clinicopathologic parameters and patient survival was processed statistically. In 63 samples of astrocytoma, 36 cases were immunoreactive for beta-catenin at cytoplasm, ten cases of astrocytoma were immunoreactive at cytomembrane, and four cases of astrocytoma were stained for beta-catenin at nucleus. Spearman analysis showed that the distribution of beta-catenin was not correlated with the grades of astrocytoma. However, the expression profiles were correlated with the patient's 2-year survival, but not correlated with the grades, tumor size, sex, age, or tumor location. Patients with low beta-catenin expression levels tended to be associated with a better prognosis than those who with high levels (p = 0.042). Our results suggest that beta-catenin is useful for the prognosis evaluation of astrocytoma.
本研究旨在评估β-连环蛋白在星形细胞瘤中的表达，并分析β-连环蛋白表达的临床相关性和预后意义。对 63 例星形细胞瘤切除标本进行免疫组织化学检测β-连环蛋白的表达。对免疫表达结果与临床病理参数和患者生存的相关性进行统计学分析。在 63 例星形细胞瘤标本中，36 例β-连环蛋白在细胞质中呈免疫反应性，10 例星形细胞瘤在细胞质膜中呈免疫反应性，4 例星形细胞瘤β-连环蛋白在核中染色。Spearman 分析表明，β-连环蛋白的分布与星形细胞瘤的分级无关。然而，表达谱与患者的 2 年生存率相关，但与分级、肿瘤大小、性别、年龄或肿瘤部位无关。β-连环蛋白低表达水平的患者预后较好，与高表达水平的患者相比（p = 0.042）。我们的结果表明，β-连环蛋白可用于评估星形细胞瘤的预后。
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