Chi Tian-Yan, Wang Li-Hua, Qu Chan, Yang Bai-Zhen, Ji Xue-Fei, Wang Yi, Okuyama Toru, Yoshihito Okada, Zou Li-Bo
Department of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China.
J Asian Nat Prod Res. 2009 Dec;11(12):1019-27. doi: 10.1080/10286020903337832.
This study examined the effects of xanthoceraside (1) on learning and memory impairment induced in mice by intracerebroventricular injection of aggregated peptide beta-amyloid 25-35 (Abeta(25-35)). Learning and memory functions in mice were examined using step-through, Y-maze and water maze tests. Administration of 1 reduced the number of errors and prolonged latency in the step-through test in mice impaired by Abeta(25-35). Likewise, latency to find the terminal platform was decreased and the number of right reflects was increased in the water maze test, and the percentage of alternation behaviors in the Y-maze test was increased. Biochemical studies showed that decreased activities of superoxide dismutase, glutathione peroxidase, and acetylcholinesterase, and increased content of malondialdehyde in mice impaired by Abeta(25-35) were significantly ameliorated by administration of 1. The present results suggest that 1 may provide a potential treatment strategy for Alzheimer's disease.
本研究考察了文冠果苷（1）对脑室内注射聚集的β-淀粉样蛋白25-35（Aβ（25-35））诱导的小鼠学习记忆障碍的影响。采用避暗试验、Y迷宫试验和水迷宫试验检测小鼠的学习记忆功能。给予1可减少Aβ（25-35）损伤小鼠在避暗试验中的错误次数并延长潜伏期。同样，在水迷宫试验中，找到终点平台的潜伏期缩短，正确反应次数增加，且在Y迷宫试验中交替行为的百分比增加。生化研究表明，给予1可显著改善Aβ（25-35）损伤小鼠中超氧化物歧化酶、谷胱甘肽过氧化物酶和乙酰胆碱酯酶的活性降低以及丙二醛含量增加的情况。目前的结果表明，1可能为阿尔茨海默病提供一种潜在的治疗策略。
