Synthesis of novel 5'-uridine-head amphiphiles as model for DNA molecular recognition.

作者信息

Tiecco Matteo, Di Profio Pietro, Germani Raimondo, Savelli Gianfranco

机构信息

CEMIN-Excellence Centre on Innovative Nanostructured Materials, Department of Chemistry, University of Perugia, Perugia, Italy.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2009 Oct;28(10):911-23. doi: 10.1080/15257770903306625.

DOI:10.1080/15257770903306625

PMID:20183561

Abstract

Here we describe uridine functionalization in the 5' position, which provides new classes of cationic and nonionic amphiphiles specifically designed as DNA transfection agents. The synthetic procedures developed to obtain the cationic uridine-head surfactants prevented intramolecular cyclization that occurs when uridine is functionalized in this position without using protecting groups in the uracil.

摘要