Mináriková P, Zavoral M
Interní klinika 1. lékarské fakulty UK a UVN Praha.
Vnitr Lek. 2010 Jan;56(1):44-8.
Gastrointestinal tract tumours represent an important cause of death in the Czech Republic. Diagnosis of the disease at its advanced stage with progression precluding radical surgical solution is a frequent common denominator. Detection of precancerous states, including congenital genetic defects or premalignant syndromes and malignant lesions may serve as a useful tool for early detection of disease risk or disease onset. Considering the incidence of individual types of tumours, this paper Focuses mainly on precancerotic states leading to malignant alterations of oesophagus, colorectum and pancreas. Apart from a concise morphological description of each premalignancy and its malignant transformation, a description of traditional molecular models of development and progression is also provided. Furthermore, we include a brief list of the most important genes contributing to the mechanism of malignant transformation in these three most important tumour diseases.
在捷克共和国，胃肠道肿瘤是一个重要的死亡原因。疾病在晚期被诊断出来且病情进展排除了根治性手术解决方案是常见的情况。检测癌前状态，包括先天性基因缺陷或癌前综合征以及恶性病变，可能是早期发现疾病风险或疾病发作的有用工具。考虑到各类肿瘤的发病率，本文主要关注导致食管、结肠直肠和胰腺发生恶性改变的癌前状态。除了对每种癌前病变及其恶性转化进行简要的形态学描述外，还提供了传统的发育和进展分子模型描述。此外，我们还简要列出了在这三种最重要的肿瘤疾病中促成恶性转化机制的最重要基因。
