Christiansen P M
Surgical Department Bispebjerg Hospital, Copenhagen, Denmark.
Scand J Gastroenterol. 1967;2(2):105-11. doi: 10.3109/00365526709180054.
Titration to different pH end points was performed in all samples of gastric juice from 208 patients with gastro- instestinal diseases and healthy persons, examined with the augmented histamine test. Titration to pH 3.3 and to pH 7.0 revealed differences in hydrogen ion concentration, which were significantly negatively correlated to the maximal acid output, calculated from the acidity at pH 3.3. Differences between maximal acid outputs, calculated from the acidities at pH 3.3 and pH 7.0, varied only little in all examined groups with the exception of gastric juice contaminated by food. Titration to pH 7.0 or higher overestimates gastric hydrochloric acid, especially in gastric juice from patients with gastritis and gastric juice contaminated by food. The results of this study support previous investigations, which recommend titration of gastric juice to pH 3.5 with simultaneous measurement of pH. Achlorhydria corresponding to absence of parietal cells is hereby defined by a pH higher than 3.5 and a pH fall less than one pH unit from basal to maximally stimulated values.
对208例胃肠疾病患者和健康人的所有胃液样本进行滴定至不同pH终点的操作，这些样本通过强化组胺试验进行检测。滴定至pH 3.3和pH 7.0时发现氢离子浓度存在差异，这些差异与根据pH 3.3时的酸度计算出的最大酸排出量显著负相关。根据pH 3.3和pH 7.0时的酸度计算出的最大酸排出量之间的差异，在所有检查组中除了被食物污染的胃液外变化很小。滴定至pH 7.0或更高会高估胃盐酸，尤其是在胃炎患者的胃液和被食物污染的胃液中。本研究结果支持先前的研究，这些研究建议将胃液滴定至pH 3.5并同时测量pH。对应于壁细胞缺失的无酸血症在此定义为pH高于3.5且从基础值到最大刺激值的pH下降小于一个pH单位。
