脑海绵状血管瘤合并动静脉畸形——病例报告

Cavernous angioma associated with arteriovenous malformation of the brain--case report.

作者信息

Kamiyama Hironaga, Nishimura Shinjitsu, Kaimori Mitsuhiro, Watanabe Mika, Furuno Yuichi, Saito Atsushi, Nishijima Michiharu

机构信息

Department of Neurosurgery, Aomori Prefectural Central Hospital, Aomori.

出版信息

Neurol Med Chir (Tokyo). 2010;50(2):131-4. doi: 10.2176/nmc.50.131.

DOI:10.2176/nmc.50.131

PMID:20185878

Abstract

A 61-year-old man presented a rare case of cerebral cavernous angioma associated with cerebral arteriovenous malformation (AVM) manifesting as headache. Magnetic resonance imaging showed an AVM in the right occipital lobe and a cavernous angioma in the left middle fossa. The patient underwent left frontotemporal craniotomy with total resection of the left parasellar intra-axial tumor. One month after the first operation, he underwent right occipital craniotomy with total resection of the right occipital AVM. The histological diagnoses were cavernous angioma and AVM, respectively. Immunostaining for angiogenic growth factors and structural proteins revealed different expression patterns of alpha-smooth muscle actin in these structures. Expression of structural proteins may reflect differences in their pathogenesis.

摘要

一名61岁男性出现了一例罕见的与脑动静脉畸形（AVM）相关的脑海绵状血管瘤，表现为头痛。磁共振成像显示右侧枕叶有一个AVM，左侧中颅窝有一个海绵状血管瘤。患者接受了左额颞开颅手术，完全切除了左侧鞍旁轴内肿瘤。第一次手术后一个月，他接受了右枕叶开颅手术，完全切除了右侧枕叶AVM。组织学诊断分别为海绵状血管瘤和AVM。对血管生成生长因子和结构蛋白的免疫染色显示这些结构中α平滑肌肌动蛋白的表达模式不同。结构蛋白的表达可能反映了它们发病机制的差异。