Department of Physiology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia.
Kidney Int. 2010 Mar;77(6):483-5. doi: 10.1038/ki.2009.485.
Although it has been recognized for more than 140 years that the pacemaker driving pyeloureteric peristalsis resides within the kidney, the cellular mechanisms underlying this autorhythmicity have been little investigated. The demonstration by Hurtado et al. of a role of hyperpolarization-activated cation channels in the maintenance of coordinated propagating contractions in the mouse renal pelvis raises a number of intriguing possibilities in addition to the provided correlation with 'pacemaker' function as in the heart and neurons.
尽管 140 多年来人们已经认识到，起搏器驱动肾盂输尿管蠕动的位置在肾脏内，但这种自主节律性的细胞机制尚未得到深入研究。Hurtado 等人的研究表明，超极化激活阳离子通道在维持小鼠肾盂协调传播收缩方面发挥作用，除了与心脏和神经元中的“起搏器”功能相关外，还提出了许多有趣的可能性。
