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[术后甲状旁腺功能减退,Graves病甲状腺全切除术中的一种假定风险]

[Postoperative hypoparathyroidism, an assumed risk in total thyroidectomy for Graves disease].

作者信息

Miron A, Martin S, Giulea C, Fica S

机构信息

Secţia Chirurgie Generală, Spitalul Universitar de Urgenţă Elias.

出版信息

Chirurgia (Bucur). 2009 Nov-Dec;104(6):749-52.

Abstract

Hypocalcemia is a common clinical occurrence and has many potential causes, one of which can be congenital or acquired hypoparathyroidism. Acquired hypoparathyroidism is most commonly the result of damage to the glands, usually to their blood supply, during thyroidectomy, parathyroidectomy, or radical neck dissection. We present the case of a 40-year-old female known with Waldenström macroglobulinemia, cronic hepatitis C, who has been diagnosed with Graves disease and associated ophtalmopathy in 2004 and treated with antithyroid drugs for 1.5 years; a decision of total thyroidectomy was made considering the complexity of comorbidities and the fact that the patient already had a relapse under methymazol treatment. The postsurgical evolution was impeared by a sever hypocalcemia, necessitating repeted parenteral calcium administration associated with p.o. calcium and vitamin D, with rapid recovery, seric calcium beeing kept in normal limits and without symptoms.

摘要

低钙血症是临床常见病症,有多种潜在病因,其中之一可能是先天性或获得性甲状旁腺功能减退。获得性甲状旁腺功能减退最常见的原因是在甲状腺切除术、甲状旁腺切除术或根治性颈清扫术中腺体受损,通常是其血液供应受损。我们报告一例40岁女性病例,该女性患有华氏巨球蛋白血症、慢性丙型肝炎,2004年被诊断为格雷夫斯病及相关眼病,接受抗甲状腺药物治疗1.5年;鉴于合并症的复杂性以及患者在甲巯咪唑治疗下已复发,决定行全甲状腺切除术。术后病情因严重低钙血症而受到影响,需要反复静脉注射钙剂,并口服钙剂和维生素D,患者恢复迅速,血清钙维持在正常范围且无症状。

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