Department of Psychology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
Neuron. 2010 Feb 25;65(4):550-62. doi: 10.1016/j.neuron.2010.02.005.
One of the most consistent observations in human functional imaging is that a network of brain regions referred to as the "default network" increases its activity during passive states. Here we explored the anatomy and function of the default network across three studies to resolve divergent hypotheses about its contributions to spontaneous cognition and active forms of decision making. Analysis of intrinsic activity revealed the network comprises multiple, dissociated components. A midline core (posterior cingulate and anterior medial prefrontal cortex) is active when people make self-relevant, affective decisions. In contrast, a medial temporal lobe subsystem becomes engaged when decisions involve constructing a mental scene based on memory. During certain experimentally directed and spontaneous acts of future-oriented thought, these dissociated components are simultaneously engaged, presumably to facilitate construction of mental models of personally significant events.
在人类功能成像中最一致的观察之一是，一个被称为“默认网络”的脑区网络在被动状态下增加其活动。在这里，我们通过三项研究探索了默认网络的解剖结构和功能，以解决关于其对自发认知和主动决策形式的贡献的不同假设。对内在活动的分析表明，该网络包含多个分离的成分。当人们做出与自身相关的、情感决策时，中线核心（后扣带回和前内侧前额叶皮层）活跃。相比之下，当决策涉及基于记忆构建心理场景时，内侧颞叶子系统会参与其中。在某些实验指导和自发的面向未来的思维行为中，这些分离的成分同时被激活，大概是为了促进个人重要事件的心理模型的构建。
