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胰岛素样生长因子 1、胰岛素样生长因子结合蛋白 3 及骨密度在埃及开罗慢性丙型肝炎病毒患者中的潜在作用。

The potential role of insulin-like growth factor 1, insulin-like growth factor binding protein 3 and bone mineral density in patients with chronic hepatitis C virus in Cairo, Egypt.

机构信息

Internal Medicine Department, National Research Centre, El Buhoth Street, Dokki, Cairo, 12311, Egypt.

出版信息

Trans R Soc Trop Med Hyg. 2010 Jun;104(6):429-32. doi: 10.1016/j.trstmh.2010.01.012. Epub 2010 Mar 1.

DOI:10.1016/j.trstmh.2010.01.012
PMID:20189618
Abstract

Insulin-like growth factor 1 (IGF-1) levels have been found to correlate with measurements of bone mineral density (BMD) in liver diseases. This study investigated the relationship between IGF-1, insulin-like growth factor binding protein 3 (IGFBP-3) and BMD in patients with chronic hepatitis C virus. This study was conducted for 30 patients with chronic hepatitis C virus infection (16 patients without and 14 patients with cirrhosis) and 11 healthy controls. Serum levels of IGF-1 and IGFBP-3 and BMD of the proximal femur and lumbar spine were measured in all subjects. Osteoporosis of the proximal femur and lumbar spine was found in 42.9% and 21.4%, respectively, of the patients with cirrhosis. Patients with liver cirrhosis and osteoporosis of the proximal femur and lumbar spine had lower IGF-1 (P<0.001, P=0.04, P=0.04 respectively). BMD of the proximal femur was lower in cirrhotic patients compared with controls (P<0.01). Patients with liver cirrhosis had lower IGFBP-3 than patients without cirrhosis and controls (P<0.001). Patients with osteoporosis of the proximal femur had lower IGFBP-3 than those without osteoporosis (P<0.01). IGF-1 and IGFBP-3 levels were lower in patients with liver cirrhosis. IGF-1 and IGFBP-3 may play a role in hepatic osteoporosis.

摘要

胰岛素样生长因子 1（IGF-1）水平与肝脏疾病的骨密度（BMD）测量值相关。本研究调查了慢性丙型肝炎病毒患者中 IGF-1、胰岛素样生长因子结合蛋白 3（IGFBP-3）和 BMD 之间的关系。该研究共纳入 30 例慢性丙型肝炎病毒感染患者（16 例无肝硬化和 14 例肝硬化）和 11 例健康对照者。所有受试者均测量血清 IGF-1 和 IGFBP-3 水平以及股骨近端和腰椎的 BMD。肝硬化患者的股骨近端和腰椎骨质疏松症的发生率分别为 42.9%和 21.4%。患有肝硬化和股骨近端及腰椎骨质疏松症的患者 IGF-1 水平较低（P<0.001，P=0.04，P=0.04 分别）。与对照组相比，肝硬化患者的股骨近端 BMD 较低（P<0.01）。肝硬化患者的 IGFBP-3 水平低于无肝硬化患者和对照组（P<0.001）。股骨近端骨质疏松症患者的 IGFBP-3 水平低于无骨质疏松症患者（P<0.01）。肝硬化患者的 IGF-1 和 IGFBP-3 水平较低。IGF-1 和 IGFBP-3 可能在肝性骨质疏松症中发挥作用。

相似文献

[1]
The potential role of insulin-like growth factor 1, insulin-like growth factor binding protein 3 and bone mineral density in patients with chronic hepatitis C virus in Cairo, Egypt.

Trans R Soc Trop Med Hyg. 2010-3-1

[2]
Bone mineral density, serum insulin-like growth factor I, and bone turnover markers in viral cirrhosis.

Hepatology. 1998-9

[3]
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Exp Clin Endocrinol Diabetes. 2004-1

[4]
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J Bone Miner Res. 1998-5

[5]
Possible contribution of serum activin A and IGF-1 in the development of hepatocellular carcinoma in Egyptian patients suffering from combined hepatitis C virus infection and hepatic schistosomiasis.

Clin Biochem. 2006-6

[6]
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Calcif Tissue Int. 2002-10

[7]
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[8]
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J Bone Miner Metab. 2004

[9]
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J Clin Gastroenterol. 2011-7

[10]
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Zhonghua Wei Chang Wai Ke Za Zhi. 2009-5

引用本文的文献

[1]
Abnormal Trabecular and Cortical Bone Microarchitecture in Chronic Hepatitis C Infection and Associations With Select Inflammatory Cytokines.

Open Forum Infect Dis. 2025-4-29

[2]
Bone mineral density loss in patients with cirrhosis.

Saudi J Gastroenterol. 2018

[3]
Insulin-Like Growth Factor (IGF) System in Liver Diseases.

Int J Mol Sci. 2018-4-27

[4]
Reduced Serum IGF-1 Associated With Hepatic Osteodystrophy Is a Main Determinant of Low Cortical but Not Trabecular Bone Mass.

J Bone Miner Res. 2017-11-6

[5]
Hepatitis C virus infection and risk of osteoporosis: A meta-analysis.

Saudi J Gastroenterol. 2017

[6]
Males seropositive for hepatitis B surface antigen are at risk of lower bone mineral density: the 2008-2010 Korea National Health and Nutrition Examination Surveys.

Hepatol Int. 2016-2-5

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