p62，自噬的英雄还是罪魁祸首？
p62, an autophagy hero or culprit?
机构信息
Centre for Cancer Biomedicine, University of Oslo and Department of Biochemistry, The Norwegian Radium Hospital Montebello, N-0310, Oslo, Norway.
出版信息
Nat Cell Biol. 2010 Mar;12(3):207-9. doi: 10.1038/ncb0310-207.
PMID:20190829
Abstract
The p62 protein recognizes toxic cellular waste, which is then scavenged by a sequestration process known as self-eating or autophagy. Lack of autophagy leads to accumulation of p62, which is not good for liver cells, as it induces a cellular stress response that leads to disease.
摘要
p62 蛋白识别有毒的细胞废物，然后通过自噬或自噬的隔离过程被清除。自噬的缺乏会导致 p62 的积累，这对肝细胞不利，因为它会引起细胞应激反应，导致疾病。
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