Sârb Simona, Cîmpean Anca Maria, Grigoraş D
Department of Histology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
Rom J Morphol Embryol. 2010;51(1):81-4.
Tie2 is a member of receptor tyrosine kinases family, involved in vasculogenesis and angiogenesis. Its main role is to stabilize, maintain, and facilitate the structural adaptation of the vasculature, during embryo development, and adult wound healing, or tumor development. Tissues from human embryos found in different stages of development (5 and 7-week-old), were investigated for Tie2 expression. The reaction was positive, with maximum intensity in the vascular cords, found in the mesenchymal tissue, and in the connective tissue around the primitive spinal cord. In the 7-week-old embryo, the reaction was negative in large blood vessels, and it was heterogeneous in those showing bridging phenomenon. In conclusion, during the first two months of human embryo development, we have concurrent vasculogenesis, angiogenesis, and blood vessel maturation and stabilization.
Tie2是受体酪氨酸激酶家族的成员，参与血管发生和血管生成。其主要作用是在胚胎发育、成人伤口愈合或肿瘤发展过程中稳定、维持并促进脉管系统的结构适应。对处于不同发育阶段（5周和7周龄）的人类胚胎组织进行了Tie2表达研究。反应呈阳性，在间充质组织和原始脊髓周围的结缔组织中的血管索中强度最大。在7周龄胚胎中，大血管中的反应为阴性，在出现桥接现象的血管中反应不均匀。总之，在人类胚胎发育的前两个月，同时存在血管发生、血管生成以及血管成熟和稳定过程。
